| Research Institutes / Centres / Groups |
Description of Role |
Date From |
Date To |
| Social Policy & Aging |
|
01-SEP-77 |
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| Position Held |
Job Description |
Where |
Date From |
Date To |
| Research Fellow |
|
University of Cambridge |
1971 |
1973 |
| Research Fellow |
|
TCD |
1973 |
1975 |
| Temporary Lecturer in Chemistry |
|
Trinity College Dublin |
1975 |
1976 |
| Research Fellow |
|
TCD |
1976 |
1977 |
| Lecturer in Chemistry |
|
TCD |
1977- |
|
| |
| Development of new methods for organic synthesis; synthesis of complex natural products, especially medium-ring and macrocyclic lactones; cycloaddition chemistry of vinylic sulfones; chemistry of sulfonyl-stabilised anions; chiral auxiliaries and reagents derived from monoterpenoids; heterocyclic chemistry, especially the chemistry of 4-dimethylaminopyridine N-oxide and some homochiral derivatives. |
| Catalysis |
Hetrocyclic chemistry |
Mechanisms of reactions |
Medicinal Chemistry |
| Organic chemistry |
Organometallic chemistry |
Quality, regulatory and GMP areas of pharmaceutical chemistry |
Spectroscopy |
| Sulfone chemistry |
| Project title |
· New routes to Loratidine, and novel Stobbe-like reactions of phosphonates and sulfones (M. Eichler) |
| Summary |
A new synthesis of the non-sedating antihistamine Loratidine that uses inexpensive starting materials has been successfully accomplished.
Unusual Stobbe-like reactions that take place between certain phosphonate anions and a series of aldehydes have been studied. A parallel series of reactions involving sulfonyl anions has been uncovered. |
| Funding Agency |
None |
| Programme |
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| Type of Project |
Organic synthesis |
| Date from |
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| Date to |
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| Person Months |
36 |
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| Project title |
· Synthesis of Novel Heteromacrocyclic Ligands and Investigation of their Properties (D. Bradley) |
| Summary |
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| Funding Agency |
EI |
| Programme |
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| Type of Project |
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| Date from |
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| Date to |
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| Person Months |
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| Project title |
· A Recyclable Auxiliary for the Asymmetric Transamination of Ketones to give Homochiral Secondary Amines (S. Baron) |
| Summary |
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| Funding Agency |
EI |
| Programme |
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| Type of Project |
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| Date from |
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| Date to |
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| Person Months |
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| Project title |
· Chiral Hypernucleophilic Acylation Catalysts for Asymmetric Synthesis (R. MacDomnhnaill) |
| Summary |
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| Funding Agency |
CSCB |
| Programme |
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| Type of Project |
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| Date from |
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| Date to |
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| Person Months |
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| Project title |
· Camphorsulfonyl-based chiral auxiliaries for asymmetric synthesis (F. Lewis) |
| Summary |
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| Funding Agency |
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| Programme |
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| Type of Project |
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| Date from |
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| Date to |
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| Person Months |
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| More Research Projects>>> |
| E. T. Gallagher and D. H. Grayson, Reactions of lithiated (E)-3-halo-1-phenylsulfonylprop-1-enes and of (Z)-1-halo-3-phenylsulfonylprop-1-enes with aldehydes, Org. Biomol. Chem., 1, 2003, p1374 - 1381 |
| D. H. Grayson, U. McCarthy and E. D. Roycroft, Intramolecular acylative ring-switching reactions of 3-(tetrahydro-2?-furyl)propanoic acid derivatives to give butanolides: mechanism and scope, Org. Biomol. Chem., 1, 2003, p1930 - 1937 |
| More Publications>>> |