Staff
| Personal Information | ||
| Name | Rozas, Isabel | |
| College Address | School of Chemistry, |
|
| Main Department | Chemistry | |
| College Title | Professor | |
| rozasi@tcd.ie | ||
| College Tel | +353 1 896 3731 | |
| Web | http://www.tcd.ie/Chemistry/staff/people/Rozas/ | |
| Fax | +353 1 671 2826 | |
| Biography | |
| Dr. Isabel Rozas was born in Madrid (Spain). After completing her BSc (hons) in Chemistry at the Complutense University, her Ph.D was embarked upon at the Instituto de Quimica Medica, National Council of Research (CSIC) in Madrid, and completed in 1987. Thereafter, she worked as a post-doctoral fellow at both the University of Saskatchewan (Canada) and Queen's University in Kingston (Canada). She worked as a researcher in CSIC until 2000, after which time she joined the School of Chemistry in TCD. | |
| Teaching interests and responsibilities | |
| I teach mostly to the Sophister years within the Medicinal Chemistry Mederatorship | |
| Professional Qualifications | |
| Qualification | Institution | Class of Degree | Title of Dissertation | Date Conferred |
| Ph.D | Universidad Complutense de Madrid | Cum Laude | 1987 | |
| Licenciado de grado | Universidad Complutense de Madrid | 1982 | ||
| B.Sc | Universidad Complutense de Madrid | Honours | 1981 |
| Administrative Functions | |
| Details | Level | Date From | Date To |
| Director of Postgraduate Teaching & Learning | 2011 | present | |
| Head of Organic, Medicinal & Biological Chemistry | 2007 | 2010 | |
| Director of the Medicinal Chemistry Course, TCD | 2003 | 2007 | |
| College Tutor | 2002 | 2004 | |
| Member of the Pharmacy School Committee | 2001 | 2007 | |
| Membership of Professional Institutions, Associations, Societies |
| Details | Date From | Date To |
| Spanish Society of Medicinal Chemistry | 1987 | present |
| World Association of Theoretical and Computational Chemists (WATOC) | 1988 | present |
| Member of the Royal Society of Chemistry | 2005 | present |
| Member of the American Chemical Society | 2008 | present |
| Awards and Honours | |
| Award | Date |
| Fellow of the Trinity College Dublin | 2005 |
| Education Details | |
| School/College | Date From | Date To |
| Universidad Complutense de Madrid | 1977 | 1981 |
| Languages |
| Language | Skill Reading | Skill Writing | Skill Speaking |
| English | Fluent | Fluent | Fluent |
| French | Medium | Basic | Basic |
| Spanish | Fluent | Fluent | Fluent |
| Research Institutes / Centres / Groups | |
| Research Institutes / Centres / Groups | Description of Role | Date From | Date To |
| Centre for Synthesis and Chemical Biology | PI | 01-OCT-01 | 31-DEC-15 |
| High Performance Computing Centre | PI | 01-OCT-01 | 31-DEC-15 |
| Trinity College Institute of Neuroscience | PI | 01-JUN-11 | 31-DEC-15 |
| Employment Details | |
| Position Held | Job Description | Where | Date From | Date To |
| Associate Professor | Trinity College Dublin | 2010 | present | |
| Senior Lecturer in Medicinal Chemistry | Trinity College Dublin | 2006 | 2010 | |
| Lecturer in Medicinal Chemistry | Trinity College Dublin | 2000 | 2006 | |
| Researcher | Institute of Medicinal Chemistry, CSIC (Madrid) | 1987 | 2000 | |
| Postoctoral Researcher | Department of Chemistry, University of Saskatchewan (Canada) | August 1989 | July 1991 | |
| More Employment Details>>> | ||||
| Description of Research Interests |
| Current research involves different areas: i) The design, synthesis and biophysical and biochemical study of new dual action agents targetting DNA as intercalators and minor-groove binders with potential as more selective anticancer drugs. ii) The design, synthesis and biophysical and biochemical study of new Pt complexes of guanidinium based DNA minor-groove binders with potential as anticancer drugs. iii) The design, synthesis and biochemical study of guanidinium derivatives of the tyrosin kinase inhibitor Sorafenib. These compounds have potential application as anticancer drugs. iv) The design, synthesis and study of the pharmacological potential of antagonists of alpha2-adrenoceptors as antidepressants. These compounds consist in bis-(amino)amidine derivatives connected by a wide range of aromatic linkers. v) The theoretical study of the nature of Hydrogen bonds and other weak interactions and their implications in chemical and biological systems by means of MO calculations and the analysis of the electron density. |
| Research Interests | |||
| Anticancer therapies | Chemistry of drug receptor interactions | Computational Biology | Computational chemistry and modelling |
| Computer assisted drug design | Depression | Design and synthesis of drugs | Drug development and evaluation |
| Drug discovery | Genitourinary, prostatic function and disease | Hetrocyclic chemistry | Hydrogen bonding |
| Malaria | Medicinal Chemistry | Molecular Biology | Neurodegeneration |
| Organic chemistry | Protein chemistry, structure and folding | Quantum chemistry | Structural Biology, Determination, Function |
| Synthesis and new molecules | Theoretical chemistry |
| Research Projects | |
| Project title | Design, synthesis and biological evaluation of new derivatives with affinity and selectivity towards alpha1A-adrenoceptors |
| Summary | |
| Funding Agency | HEA-CSCB |
| Programme | |
| Type of Project | |
| Date from | 2003 |
| Date to | 2005 |
| Person Months | |
| Project title | Towards more selective and active ligands of I2-Imidazoline Binding Sites |
| Summary | |
| Funding Agency | HEA-CSCB |
| Programme | |
| Type of Project | |
| Date from | 2002 |
| Date to | 2006 |
| Person Months | |
| Project title | New and improved derivatives of PaTrin2 as inhibitors of ATase |
| Summary | |
| Funding Agency | McElheny Memorial |
| Programme | |
| Type of Project | |
| Date from | 2004 |
| Date to | 2007 |
| Person Months | |
| Project title | Computational analysis of alpha1B and alpha1D adrenoceptor subtypes and their ligands: towards a selective interaction |
| Summary | |
| Funding Agency | HEA-IITAC |
| Programme | |
| Type of Project | |
| Date from | 2005 |
| Date to | 2008 |
| Person Months | |
| Project title | Chiral recognition in hydrogen bonded complexes |
| Summary | |
| Funding Agency | Spanish Ministry of Education |
| Programme | BQU2003-01251 |
| Type of Project | |
| Date from | 2003 |
| Date to | 2007 |
| Person Months | |
| More Research Projects>>> | |
| Publications and Other Research Outputs |
| Peer Reviewed |
| Rodriguez, F., Rozas, I., Ortega, J.E., Erdozain, A.M., Meana, J.J., Callado, L.F. , Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor ligands: searching for structure-activity relationships., Journal of Medicinal Chemistry , 52, (3), 2009, p601-609 Url DOI |
|
| D. H. O'Donovan, F. Blanco, I. Rozas, I. Alkorta, J. Elguero, Chiral recognition in bicyclic guanidines, Collect. Czech. Chem. Commun, 74, 2009, p299-312 Url |
|
| S. Lopez, T. McCabe, R. S. McElhinney, T. B. H. McMurry, I. Rozas, Syntheses of 2-amino-4,6-dichloro-5-nitropyrimidine and 2-amino-4,5,6-trichloropyrimidine: an unusual aromatic substitution, Tetrahedron Letters, 50, (44), 2009, p6022-6024 Notes: [ ] DOI |
|
| F. Rodriguez, I. Rozas, M. Kaiser, R. Brun, B. Nguyen, W.D. Wilson, R.N. Garcia, C. Dardonville, New bis(2-aminoimidazoline) and bisguanidne DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity, J. Med. Chem., , 51, (4), 2008, p909-923 Notes: [PMID: 18247550] Url DOI |
|
| G. Kinsella, I. Rozas, G. Watson, Modelling the interaction of catecholamines with the alpha1A Adrenoceptor- towards a ligand-induced receptor structure, J. Comp-Aided Mol. Des, 19, (6), 2005, p357 - 367 Notes: [PMID: 16231197 ] Url TARA - Full Text Alt. Url |
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| More Publications and Other Research Outputs >>> | |
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Last updated 9 March 2011 by .