Staff
| Personal Information | ||
| Name | Southern, John Michael | |
| College Address | School of Chemistry, |
|
| Main Department | Chemistry | |
| College Title | Assistant Professor | |
| southerj@tcd.ie | ||
| College Tel | +353 1 896 3411 | |
| Web | http://people.tcd.ie/southerj | |
| Membership of Professional Institutions, Associations, Societies |
| Details | Date From | Date To |
| Chartered Chemist and Member of the Royal Society of Chemistry |
| Awards and Honours | |
| Award | Date |
| Visiting Professor, Louvain-la-Neuve University, Belgium | Jan-Apr 2006 |
| Description of Research Interests |
| Our overall goal is to exploit synthetic chemistry to probe biological mechanisms in order to understand and provide treatment for disease. Neuronal nicotinic acetylcholine receptors are an extremely exciting set of ion channels that we are targeting by developing sub-type specific ligands. Areas of particular interest to us are: addiction, pain management, Parkinson’s disease, Alzheimer’s disease, Schizophrenia and anxiety. In another area we employ a slightly different approach. Rather than targeting specific group of receptors the focus is on the preparation of a diverse range of heterosugars, in which the endocyclic oxygen is replaced with another heteroatom e.g. sulphur, nitrogen or selenium. This class of compounds have exciting anti-viral, anti-cancer and anti-bacterial properties and they are also glycosidase inhibitors. The diseases we are targeting via this approach include Hepatitis C, HIV, avian flu, cancer, MRSA, drug resistant TB, diabetes (type 1 and type 2) and obesity. Other areas of interest include chiral alpha-oxy anions, chiral reactions of electron-rich alkenes and remote chirality |
| Publications and Other Research Outputs |
| Peer Reviewed |
| Preparation and reactions of iminophosphoranes and their synthetic applications in the aza-Wittig reaction. in, editor(s)P.J. Murphy , Organophosphorus Reagents A Practical Approach in Chemistry, Oxford University Press, 2004, pp151 - [J.Mike Southern and Ian A. O'Neil] | |
| Ian A. O’Neil, Ed Cleator, J. Mike Southern and David J. Tapolczay, The Stereospecific Addition of Hydroxylamines to a,b-Unsaturated Sulfones, Nitriles and Nitro compounds, Tetrahedron Letters, 42, 2001, p8251- | |
| Ian. A. O’Neil, Ed Cleator, J. Mike Southern, Neal Hone, David J. Tapolczay, The Synthesis of Polyhydroxylated Pyrrolidines Using a Reverse-Cope Cyclisation., Synlett, 2000, p1408- | |
| Ian. A. O’Neil, Ed Cleator, J. Mike Southern, Neal Hone, David J. Tapolczay, The Synthesis of Chiral Functionalised Piperidines Using a Reverse-Cope Cyclisation: The Effect of Solvent on Diastereoselectivity, Synlett, 2000, p695- | |
| Ian A. O’Neil, Andrew J. Potter, J. Mike Southern, Alexander Steiner and James V. Barkley, Conformationally Defined Piperazine bis(N-Oxides) Bearing Amino Acid Side Chains., Chemical Communications, 1998, p2511- | |
| I. E. Markó and J. M. Southern, Triorganothallium Reagents in Organic Chemistry. 1. A Simple, Efficient and Versatile Preparation of Ketones from Acid Chlorides, Journal of Organic Chemistry, 55, 1991, p3368- | |
| More Publications and Other Research Outputs >>> | |
| ; |